Familial risks in understanding type 1 diabetes genetics
نویسندگان
چکیده
منابع مشابه
Familial Risks for Type 2 Diabetes in Sweden
OBJECTIVE Our aim was to characterize familial risks for type 2 diabetes by the type and number of affected family members, including half-siblings, adoptees, and spouses, to quantify risks and estimate the contribution of environmental effect. RESEARCH DESIGN AND METHODS Families were identified from the Multigeneration Register, and type 2 diabetic patients were obtained from the Hospital D...
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Genetic susceptibility to type 1 diabetes (T1D) has been a subject of intensive study for nearly four decades. This article will present the history of these studies, beginning with observations of the Human Leukocyte Antigen (HLA) association in the 1970s, through the advent of DNA-based genotyping methodologies, through recent large, international collaborations and genome-wide association st...
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Type 1 diabetes is the most common autoimmune disorder in childhood, characterized by the development of autoimmunity through unknown environmental insults in genetically susceptible individuals. There are now over 50 regions of the genome that harbor type 1 diabetes susceptibility genes, with much of the genetic risk now well-defined in youth of Northern European ancestry. The impact of these ...
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Genome wide association studies (GWAS) have identified many single nucleotide polymorphisms (SNPs) that are associated with disease. GWAS typically compare allele frequencies of ∼ 500K individual SNPs in case patients to those of control patients using single-feature statistics and hundreds or thousands of patients to gain enough power to overcome the serious multiple testing hypothesis correct...
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There has been much progress in the identification of genes and molecular pathways involved in the pathogenesis of type 1 diabetes. Human histocompatibility (HLA) complex genes are the most powerful susceptibility determinants. The stronger effect is from alleles coding for selected HLA class I and class II antigen-presenting molecules, which are restricting elements for autoreactive CD8 and CD...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2012
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg3069-c1